Are you newly diagnosed? We can help. We can help.
Are you newly diagnosed? We can help. We can help.
What is Angelman syndrome?
Angelman syndrome is a rare neurogenetic disorder that affects the nervous system, causing developmental delays, significant challenges with speech and communication, and difficulties with movement and balance.
It is estimated to affect approximately 1 in 15,000 people worldwide.
How FAST Advances Research
Translational research to transformative therapeutics
FAST works to move promising Angelman syndrome research toward treatments. We invest in science, address critical gaps in drug development, and build the partnerships and resources needed to help promising approaches advance.
Our work goes beyond funding individual projects. We are helping create the conditions for scientific discoveries to become potential treatments.
Invested since 2008
Grants awarded by FAST
Current FAST-funded therapeutic programs
Multiple Paths Toward Treatments
The Angelman syndrome drug development pipeline includes 26 programs pursuing different approaches to potential treatments. FAST has helped build and advance this growing pipeline, providing funding and support to 13 programs, including research that has progressed toward clinical development.
From approaches designed to reactivate UBE3A to gene therapies and other technologies, this growing pipeline reflects the breadth of scientific innovation underway and FAST’s sustained commitment to moving promising research forward.
Latest News
- Industry
On October 8, 2026, ASF and FAST hosted a webinar with Ultragenyx after the announcement that their phase 3 trial for GTX-102 (aspire) did not meet primary or key secondary
- Fundraising
Before Sonia and her son José set off on Peru’s Inca Trail this September, their guides gave the group two goals: survive first, and finish if you can. For Sonia
- Industry
Read the press release
- Research
At INSYNC-AS 2026, researchers came together to examine how genes beyond UBE3A and differences within UBE3A itself may shape Angelman syndrome and future therapeutic development. Why can Angelman syndrome (AS)
- Industry
Be Part of the Progress
Advocate
Help bring the community’s voice into decisions that shape research and treatment development.
Participate in Research
Explore opportunities to contribute to research and future treatments.