Our Research & Impact

Roadmap Impact Research Grants

FAST is the largest non-governmental funder of Angelman syndrome research.

invested since 2011
forecast for 2018-19
total over eight years

Brightest minds partner in race for cure
FAST brought together a multidisciplinary team of more than two-dozen scientists from top research universities and pharmaceutical companies. These men and women are the world’s leading experts on Angelman syndrome (AS), and they have joined forces on a focused path to a cure.


The “FIRE” Consortium: FAST Integrative Research Environment includes five expert laboratories from four universities. The team works collaboratively to find treatments for Angelman syndrome and, ultimately, a cure. Led by Edwin Weeber, Ph.D., University of South Florida, the FIRE Team has already cured the symptoms of the disorder in mice using several strategies.

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Penn Team

Renowned gene therapy pioneer James M. Wilson, M.D., Ph.D., and his team from Penn Medicine’s Orphan Disease Center, recently joined forces with FAST to develop a treatment for AS. Wilson was recognized as one of 12 leading pioneers in cell and gene research with the Pioneer Award given by Human Gene Therapy, a peer-reviewed journal of the medical research community.

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Roadmap to a Cure



FAST is finalizing the scientific foundational work necessary to test therapies in human clinical trials. Please take a moment to read on and learn how our Roadmap to a Cure will change the lives of people with Angelman syndrome and, potentially, millions more who have related disorders like autism and Alzheimer’s disease.

FAST’s Roadmap is focused on three strategies to treat Angelman syndrome. AS is not a degenerative disorder, and these approaches, which have already been tested in animal models, are believed to have the potential to reverse the effects of the disorder in children, teens and adults.


To learn more about FAST’s Roadmap to a Cure, click here.

The Impact

A cure for Angelman syndrome will have a tremendous impact on society at large. The gene that causes Angelman syndrome has been linked to several other diseases and genetic disorders involving learning and memory. The work FAST researchers are doing may be the gateway to therapies for other disorders that affect the lives of millions.

  • There is a known correlation between Rett syndrome and Angelman syndrome.
  • There is a known correlation between Fragile X syndrome and Angelman syndrome.
  • There is a known correlation between ALS and Angelman syndrome.
  • There is a genetic link between Angelman syndrome and autism.
  • The AS protein UBE3A is decreased in Alzheimer’s disease. Amyloid Precursor Protein is a target of UBE3A.
  • Researchers understand the genetic cause of epilepsy for individuals with Angelman syndrome.

Because we know exactly what causes AS and it has already been cured in the laboratory, an investment in FAST is an investment of global proportion.

FAST-Funded Research


Funding Forecast 2018-2019

Apply for Grants

FAST is committed to bringing practical treatments for Angelman syndrome (AS) into current medical practice as quickly as possible. While our priority is on funding translational and clinical research, we also support high-risk/high-reward discovery projects. FAST’s research program awards grants to the world’s best scientists who are focused on discovering and developing treatments, technologies and ultimately a cure benefiting those with AS.

The current focus of FAST-funded research is in supporting projects that have the potential for an immediate high impact on the Angelman community; therefore, priority will be given to research-based translational grants or those showing high promise for translating basic biomedical knowledge into clinical application.

FAST’s research program funds are raised exclusively through donations and grassroots fundraising activities initiated by FAST, our supporters and families of children with Angelman syndrome.

FAST offers the following grant programs:

FAST Targeted Research to Advance a Cure (FAST TRAC) Awards
FAST Grant-in-Aid
Postdoctoral Fellowships

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As diverse as our Angelman community is, we are all united in one goal: a better future for our children. FAST is committed to bringing life-changing treatments to clinical trials within two years, but we need your help.