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Isogenically Controlled Human Cell Lines Targeting Aberrant Imprinting Genotypes

$334,786 2021

Isogenically Controlled Human Cell Lines Targeting Aberrant Imprinting Genotypes

Albert Keung, PhD

Dr. Keung and his team at North Carolina State University will provide the Angelman syndrome research community a set of cell lines that can be used to efficiently model the biology of ICD and UPD, as well as organoids that model the mosaic genotype. This will aim to help understand any potential impact of gene overexpression in these different genotypes.

FT2021-002