Evaluation of IGF-2 and IGF-2 Receptor Ligand (L1) in a Rat Model of AS on Neurobehavioral Phenotype

The goals of this project are to evaluate the effects of IGF2 and IGF2RL in AS rat model in domains of: ultrasonic communication, motor function, learning and memory, and gait as well as structural rescue by MRI (e.g. white matter loss).