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Evaluation of IGF-2 and IGF-2 Receptor Ligand (L1) in a Rat Model of AS on Neurobehavioral Phenotype

$203,948 2018

Evaluation of IGF-2 and IGF-2 Receptor Ligand (L1) in a Rat Model of AS on Neurobehavioral Phenotype

Jill Silverman, PhD

The goals of this project are to evaluate the effects of IGF2 and IGF2RL in AS rat model in domains of: ultrasonic communication, motor function, learning and memory, and gait as well as structural rescue by MRI (e.g. white matter loss).

FT2018-006