UNC Brain Development Study of Infants with AS

Recruitment is open for an NIH-funded observational study of infants with Angelman syndrome – the first longitudinal brain and behavior study of AS in infancy of its kind. This study is currently enrolling infants 0-24 months of age to participate in a non-invasive (no sedation or anesthesia involved) MRI brain scan during natural sleep as well as a series of behavioral assessments to analyze development. 

The study is aimed to determine the relationships between early brain features, behavioral symptoms, and the physiology of cerebrospinal fluid (CSF), which can be viewed with a non-invasive MRI brain scan. The goal of this research is to identify early biomarkers that could help identify novel therapeutic targets and treatment strategies for these individuals.

This study is led by Principal Investigator: Mark Shen, PhD, Assistant Professor of Psychiatry & Neuroscience, UNC School of Medicine.

Contact UNC: To enroll or ask questions, please contact: Zumin Chen (Study Coordinator) Phone: +1 919-966-8032 Email:

Compensation: All travel costs to Chapel Hill, North Carolina (airfare, hotel, rental car, meals) will be covered by the study. In addition, your family will be compensated up to $200 for your participation in this study.

Learn more here.