FAST Supported Research
FAST has numerous research grants that are active and ongoing in different research facilities around the world.
Recent examples of FAST grants include powerful work from Dr. Jim Wilson (hUBE3a, miRNA, CRISPR AAV delivery for gene replacement or gene-editing); Dr. Bryce Reeve for the development of a novel communication endpoint for Angelman syndrome; Dr. Yong-Hui Jiang, who created a biorepository to include all genotypes for AS cell lines; Dr. Albert Keung, who developed landing pads in AS organoids to test drugs for all genotypes including large deletion (genes outside of UBE3A), mutation, UPD/ICD and mosaic; Drs. Jill Silverman, Dave Segal and Kyle Fink at UC Davis to create an AS animal testing facility for all pharma to utilize in early stage POC studies; and more.
In addition to grants funded by FAST, in October 2023, the National Institutes of Health awarded the first phase of a roughly $40m grant to Yale University to advance a novel CRISPR-based gene-editing delivery platform for the targeted treatment of neurogenetic diseases. The two diseases being targeted in the project are Angelman syndrome and H1-4 (HIST1H1E) syndrome.