Recruiting
Use of Eye Tracking to Study Social Perception Abnormalities in Children With Angelman Syndrome
About this study
Angelman syndrome (AS) is a rare neurogenetic disorder that affects approximately 1 in 15,000 children - approximately 500,000 people worldwide. It is a major neurodevelopmental disorder characterized by severe developmental delay with significant intellectual disability, lack of oral language, motor, balance, and sensory impairments.
While basic research and clinical trials are progressing, the scientific community is still searching for key biomarkers to assess significant improvements in individuals participating in clinical trials.
Eye tracking has been widely used in the diagnosis of social perception abnormalities in children with autism spectrum disorder, as has already been the case for other rare neurodevelopmental diseases. However, few studies have highlighted the usefulness of eye tracking as a diagnostic tool for social behavioral disorders in individuals with Angelman syndrome. Given the prevalence of autistic-like symptoms in patients with AS, if eye-tracking can identify abnormalities in social perception in children with Angelman syndrome, these measurements could become a biomarker for therapeutic studies in these patients.
Study locations
France
State / region not reported
Paris (1)
- Hôpital Necker-Enfants Malades — Recruiting
Contact information
- Nathalie MD, PhD Boddaert
0033171396530
nathalie.boddaert@aphp.fr - Victor Bruyere
0033134292324
victor.bruyere@aphp.fr
Full registry eligibility criteria
Inclusion Criteria: * 40 children with Angelman syndrome diagnosed by genetic assessment or EEG. * 20 healthy volunteer control children with no known genetic or psychiatric neurological pathology. * Aged between 3 - 17 years. * Male or female. * Holders of parental authority and minors informed and not opposed to participation in the research. Exclusion Criteria: * Refusal to participate in the study.
Important information
Registry information may change. FAST context and classifications are editorial additions. Inclusion does not confirm eligibility or availability at a specific site. Review the official record and contact the study team for participation requirements.