Non-Invasive Prenatal Screening (NIPS) for Genetic Conditions

Non-invasive prenatal screening (NIPS, also known as cell-free fetal DNA and by the brand name Natera Panorama) is a newer technology that may be offered to pregnant individuals and may include Angelman syndrome (AS).  This screening looks at fetal DNA in the maternal blood, checking for certain chromosome differences including Down syndrome and some common genetic conditions caused by deletions. Some versions of this screening include AS, while other versions only include chromosome differences that affect whole chromosomes like Down syndrome or trisomy 18. NIPS is typically performed around 10 weeks of pregnancy.  

NIPS was not initially developed to incorporate family history. NIPS can only identify the chromosome Deletion genotype of Angelman syndrome (AS).

NIPS can not currently detect Mutation, ICD, or UPD Angelman syndrome.

If you have a child living with AS or a family history of AS, NIPS may not be able to accurately determine the chance for the current pregnancy to have AS. If you have a child living with AS or a family history of AS, it is very important that you consult an obstetrics or prenatal genetic counselor or genetic specialist to discuss the chances and which screens or tests may be most appropriate for you.   

It is very important to review your results with your pregnancy healthcare providers, as they may have important implications for both you and the fetus.

Please note the information provided here is meant as an educational resource; it is not specific to your pregnancy or your family.  It should not be considered medical advice and is not meant to replace genetic counseling or prenatal healthcare. 

If you have any questions, please consult an obstetrics or prenatal genetic counselor or genetic specialist to discuss the results and which follow-up tests may be most appropriate for you.